Composition: Each 1ml contains: Levamisole hydrochloride 30 mg. Oxyclozanide 60 mg.
Properties: Levafluke suspension is a broad spectrum anthelmintic combination contains levamisole hydrochloride as antinematoda and oxyclozanide as a fasciolicide in suspension form. Levamisole is the l isomer of dl-tetramisole. It has a paralyzing action on nematodes. The paralysis is due to sustained muscle contraction. Levamisole acts as a ganglion stimulant (cholinomimetic).
Oxyclozanide is a salicylanilide with specific activity against adult liver flukes. Its mode of action is based on alteration of phosphorylase link in energy metabolism of worm, and may also inhibit fumarate reductase activity.
Indications: Levafluke suspension is indicated for the treatment of the following:
- Parasitic gastro-enteritis caused by; Haemonchus spp., Ostertagia spp. (including type II Ostertagiasis), Trichostrongylus spp., Cooperia spp., Bunostomum spp. and Oesophagostomum spp. sensitive to levamisole in cattle and sheep.
- Parasitic bronchitis caused by Dictyocaulus viviparous sensitive to levamisole in cattle and D. filaria sensitive to levamisole in sheep.
- Fascioliasis caused by adult Fasciola hepatica and F. gigantica sensitive to oxyclozanide in cattle
Dosage & administration:
Cattle & sheep : 2.5 ml of Levafluke / 10 kg b.wt to be given orally as a drench as single dose.
Shake well before use
- Operators should wear suitable protective clothing as levamisole may cause idiosyncratic reactions and serious blood disorders in a small number of people. Seek medical advice immediately if dizziness, nausea, vomiting, abdominal discomfort, sore mouth or throat, or fever occur.
- Use cautiously or preferably delay use in cattle under stress.
- Not used for dairy cattle or sheep producing milk for human consumption.
- Not used within 14 days of treatment with organophosphorus compounds or diethylcarbamazine.
- Not used in concurrent with pyrantel, morantel, neostigmine or chloramphenicol.
- Adverse effects that may be seen in cattle can include muzzle-foaming or hypersalivation, excitement or trembling, lip-licking and head shaking. These effects are generally noted with higher than recommended doses or if levamisole is used concomitantly with organophosphates.
- In sheep, levamisole may cause a transient excitability in some animals after dosing.
- At 25 mg/ kg oxyclozanide dose levels, animals may show softening of the feces, increased frequency of defecation, slight depression and inappetence.
Withdrawal periods: Meat of cattle and sheep: 5 days.
Packs: 100, 500, 1000 & 4500 ml.